Correlation of Caesarean Section Rates to Maternal and Neonatal Mortality in the Eastern Mediterranean Region; A Population-Based Ecological Study

Authors

  • Bismeen Jadoon World Health Organization Regional Office for the Eastern Mediterranean, Nasr City, Cairo, Egypt
  • Ramez Mahaini World Health Organization Regional Office for the Eastern Mediterranean, Nasr City, Cairo Egypt
  • Karima Gholbzouri World Health Organization Regional Office for the Eastern Mediterranean, Nasr City, Cairo Egypt
  • Maha El-Adawy World Health Organization Regional Office for the Eastern Mediterranean, Nasr City, Cairo Egypt
  • Mona Ahmed Elawady El-Shaheed Farid Nada, Banha, Egypt
  • Tamer Mahmoud Assar El-Shaheed Farid Nada, Banha, Egypt

Keywords:

Caesarean Section, Maternal and Neonatal Mortality, Eastern Mediterranean Region.

Abstract

Purpose: This study aims to explore the relationship between population-level caesarean section rates (CSRs) with maternal and neonatal mortality rates (MMR, NMR) in the Eastern Mediterranean Region (EMR). Design: A populationbased ecological study was performed with data obtained from the World Health Organization, Global Health Observatory database, 2015, United Nations Inter-agency Group for Child Mortality Estimation (UN-IGME) and the United Nations Maternal Mortality Estimation Inter-Agency Group (UN-MMEIG) 2015). Mean ± standard deviation (SD), range, median and Inter quartile range (IQR) were used to describe the quantitative data. We performed multivariate logistic regression analysis to explore the effect (a) of (a) Antenatal clinic visits (ANC %), (b), Skilled Birth Attendance (SBA) rate (% of deliveries attended by SBA), (c) Total Health Expenditure (THE) per capita and (d) Female Literacy Rate (FLR%) on the studied relationship. Spline linear regression was used to find the most predictive variable for MMR, and the NMR. Statistical significance was accepted at P<0.05. Results: The mean CSR was 21.20±13.38, (1.8-52). The CSR of <10% was linked with the highest NMR and MMR, 33.0 (24.0-39.0) and 390.5(329.5-648.0) respectively. The most predictable variables for NMR and MMR were SBA % [B=-0.875; p< .001; R2=0.766 and adjusted R2=0.754] and FLR (F=15-24) [B=0.877; P<0.001; R2=0.77 and adjusted R2=0.758] respectively. Conclusions: We found a statistically significant inverse relationship between CSRs and maternal and neonatal mortality in MSs with <10% of CSR. The improved mortality rates in MSs with >15% of CSR were significantly linked with better socioeconomic and healthcare variables than higher CSRs.

References

Betran AP, Torloni MR, Zhang J, et al. What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies. Reprod Health. 2015;12:57. https://doi.org/10.1186/s12978-015-0043-6

Boerma, Ties et al Global epidemiology of use of and disparities in caesarean sections. Lancet.2018 392 (10155). pp. 1341-1348. ISSN 0140-6736 https://doi.org/10.1016/S0140-6736(18)31928- 7

Ye J, Zhang J, Mikolajczyk R, Torloni MR, Gülmezoglu AM, Betran AP. Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data. BJOG. 2016;123(5):745–753. https://doi.org/10.1111/1471-0528.13592

Esteves-Pereira AP, Deneux-Tharaux C, Nakamura-Pereira M, Saucedo M, BouvierColle MH, Leal Mdo C. Caesarean Delivery and Postpartum Maternal Mortality: A PopulationBased Case Control Study in Brazil. PLoS One. 2016 Apr 13;11(4). https://doi.org/10.1371/journal.pone.0153396

Sine´ad M, O’Neill, Patricia M. Kearney, Louise C. Kenny, Ali S. Khashan, Tine B. Henriksen, Jennifer E. Lutomski, Richard A. Greene1Caesarean Delivery and Subsequent Stillbirth or Miscarriage: Systematic Review and Meta-Analysis, 2013 | Volume 8 | Issue 1. https://doi.org/10.1371/journal.pone.0054588

Summary report on the High-level meeting on saving the lives of mothers and children: rising to the challenge in the Eastern Mediterranean Region. Dubai, United Arab Emirates, 29–30 January2013. http://applications.emro.who.int/docs/IC_Meet_ Rep_2013_EN_14862.pdf

Althabe F, Sosa C, Belizán JM, Gibbons L, Jacquerioz F, Bergel E.Cesarean section rates and maternal and neonatal mortality in low-, medium-, and high-income countries: an ecological study.Birth. 2006 Dec; 33(4):270-7. https://doi.org/10.1111/j.1523- 536x.2006.00118.x

Betrán AP, Ye J, Moller A-B, Zhang J, Gülmezoglu AM, Torloni MR. The Increasing Trend in Caesarean Section Rates: Global, Regional and National Estimates: 1990-2014. Zeeb H, ed. PLoS ONE. 2016; 11 (2). https://doi.org/10.1371/journal.pone.0148343

World Health Statistics 2015. Geneva: World Health Organization; 2015 (http://www.who.int/gho/publications/world_hea lth_statistics/2015/en/, accessed 2 May 2019). https://doi.org/10.26719/2015.21.6.379

Sobhy S, Arroyo-Manzano D, Murugesu N, et al. Maternal and perinatal mortality and complications associated with caesarean section in low-income and middle-income countries: a systematic review and metaanalysis. 2019.The Lancet. https://doi.org/10.1016/s0140-6736(18)32386-9

UNICEF Somalia. (2006). Multiple Indicator Cluster Survey (MICS).

World Health Organization (2008). The proportion of births attended by a skilled attendant: 2008 updates. Department of Reproductive Health and Research Factsheet. Geneva. Available from.

World Health Organization, Regional Office for the Eastern Mediterranean. Summary report on the expert group meeting on the regional framework for action on strengthening nursing and midwifery in the Eastern Mediterranean Region 2015–2025, Abu Dhabi, United Arab Emirates 25–26 March 2016. http://www.who.int/iris/handle/10665/252826

Afghan Public Health Institute, Ministry of Public Health (APHI/MoPH)

[Afghanistan], Central Statistics Organization (CSO)

[Afghanistan], ICF Macro, Indian Institute of Health Management Research (IIHMR)

[India], and World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO)

[Egypt]. 2011. Afghanistan Mortality Survey 2010. Calverton, Maryland, USA: APHI/MoPH, CSO, ICF Macro, IIHMR and WHO/EMRO.

World Health Statistics 2015. Geneva: World Health Organization; 2015 (http://www.who.int/gho/publications/world_health _statistics/2015/en/, accessed 2 May 2019).

Al Rifai, R.H. Trend of caesarean deliveries in Egypt and its associated factors: evidence from national surveys, 2005–2014. BMC Pregnancy Childbirth 17, 417 (2017). https://doi.org/10.1186/s12884-017-1591-

Carla AbouZahr, Global burden of maternal death and disability, British Medical Bulletin, Volume 67, Issue 1, December 2003, Pages 1–11. https://doi.org/10.1093/bmb/ldg015

Daskalakis G, Anastasakis E, Papantoniou N, Mesogitis S, Theodora M, Antsaklis A. Emergency obstetric hysterectomy. Acta Obstet Gynecol Scand. 2007;86(2):223-7. https://doi.org/10.1080/00016340601088448

Egypt Demographic Health Survey, 2014. https://dhsprogram.com/pubs/pdf/FR302/FR302. pdf

Carayol, M. , Zein, A. , Ghosn, N. , Du Mazaubrun, C. and Breart, G. (2008), Determinants of caesarean section in Lebanon: geographical differences. Paediatric and Perinatal Epidemiology, 22: 136-144. https://doi.org/10.1111/j.1365-3016.2007.00920.x

Mumtaz S, Bahk J, Khang YH. Rising trends and inequalities in cesarean section rates in Pakistan: Evidence from Pakistan Demographic and Health Surveys, 1990-2013. PLoS One. 2017 Oct 17;12(10):e0186563. https://doi.org/10.1371/journal.pone.0186563

GBD 2015 Eastern Mediterranean Region Maternal Mortality Collaborators Int J Public Health .2018, 63(Suppl 1): 47. https://doi.org/10.1007/s00038-017-1004-3

Abdel-Tawab Nahla, Oraby Doaa, Hassanein Nevine, El-Nakib Shatha. Caesarean section deliveries in Egypt: Trends, practices, receptions, and cost, Technical report, Population Council, 2018. https://doi.org/10.31899/rh6.1004

Huster KM, Patterson N, Schilperoord M, Spiegel P. Cesarean sections among Syrian refugees in Lebanon from december 2012/january 2013 to june 2013: probable causes and recommendations. Yale J Biol Med. 2014 Sep 3;87(3):269-88. PMID: 25191143; PMCID: PMC4144282

Gibbons, Luz, MSc, et al. “Inequities in the Use of Cesarean Section Deliveries in the World.” American Journal of Obstetrics and Gynecology, vol. 206, no. 4, 2012, pp. 331.e1–331.e19. https://doi.org/10.1016/j.ajog.2012.02.026

Molina G, Esquivel MM et al. Avoidable maternal and neonatal deaths associated with improving access to cesarean delivery in countries with low cesarean delivery rates: an ecological modeling analysis. Lancet. 2015. https://doi.org/10.1016/s0140-6736(15)60828-5

World Health Organization, Health inequities in the Eastern Mediterranean Region: selected country case studies. 2014. Regional Office for the Eastern Mediterranean, http://applications.emro.who.int/dsaf/emropub_20 15_1863.pdf

Gebhardt, G.S, et al. “Maternal Death and Caesarean Section in South Africa: Results from the 2011 - 2013 Saving Mothers Report of the National Committee for Confidential Enquiries into Maternal Deaths.” South African Medical Journal, vol. 105, no. 4, 2015, pp. 287–291. https://doi.org/10.7196/samj.9351

Souza JP, et al. Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study. Lancet. 2013 May 18;381(9879):1747-55.

Downloads

Published

2021-04-28

Issue

Section

Articles