Pain, An Atypical Presentation of Endometrial Cancer: Case Report and Literature Review


  • Oroma Nwanodi Women’s Health Department, Myrtle Hilliard Davis Comprehensive Health Centers, - Homer G. Phillips Health Center, 2425 North Whittier Avenue, Saint Louis MO 63113, USA
  • Neekianund Khulpateea Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn NY 11219, USA



Abdominal pain, Bone pain, Endometrial cancer, Initial presentation.


Endometrial cancer, the most common gynecologic malignancy in women in the United States typically presents with abnormal uterine bleeding. Given a case of endometrial cancer presenting as abdominal pain, we reviewed the different circumstances in which pain is the primary presenting symptom of endometrial cancer. Forty-one cases of endometrial carcinoma, were found. Patients presenting with bone pain were statistically significantly more likely to have a longer time to correct diagnosis (p<0.001), and to have metastatic disease than patients presenting with abdominal pain (p=0.001). Abdominal pain was more likely an initial presentation of endometrial cancer (p=0.003), to occur following any radiation treatment (p=0.001), and subsequent to irradiation for cervical cancer (p= 0.002), than was bone pain. Nevertheless, 21 of 32 cases (65.6%) of endometrial cancer presenting with pain for which stage is known, have advanced disease, confirming the widely held opinion that pain in endometrial cancer is indicative of advanced stage disease.


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