Congenital Chloride Diarrhoea: A Protocol for Antenatal Management
DOI:
https://doi.org/10.14205/2309-4400.2013.01.01.7Keywords:
Chloride losing diarrhoea, Saudi Arabia.Abstract
Chloride losing diarrhoea (CLD) is an autosomal recessively inherited disease characterised by lifelong chloride rich chronic diarrhoea which starts in-utero. Early diagnosis and proper replacement therapy are important to avoid serious complications of the disease. This series of cases present the tools used for in-utero diagnosis of CLD and the protocol for antenatal management adopted to achieve the best possible maternal and foetal outcomes.
References
Hoglund P, Auranen M, Socha J, Popinska K, Nazer H, Rajaram U, et al. Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait. Am J Hum Genet 1998; 63(3): 760- 8. http://dx.doi.org/10.1086/301998
Hoglund P, Holmberg C, Sherman P, Kere J. Distinct outcomes of chloride diarrhoea in two siblings with identical genetic background of the disease: implications for early diagnosis and treatment. Gut 2001; 48(5): 724-7. http://dx.doi.org/10.1136/gut.48.5.724
Holmberg C, Perheentupa J, Launiala K, Hallman N. Congenital chloride diarrhoea. Clinical analysis of 21 Finnish patients. Arch Dis Child 1977; 52(4): 255-67. http://dx.doi.org/10.1136/adc.52.4.255
Tsukimori K, Nakanami N, Wake N, Masumoto K, Taguchi T. Prenatal sonographic findings and biochemical assessment of amniotic fluid in a fetus with congenital chloride diarrhea. J Ultrasound Med 2007; 26(12): 1805-7.
Grgic O, Matijevic R, Kuna K. Raised electrical uterine activity and shortened cervical length could predict preterm delivery in a low-risk population. Arch Gynecol Obstet 2012; 285(1): 31-5. http://dx.doi.org/10.1007/s00404-011-1906-x
Wedenoja S, Hoglund P, Holmberg C. Review article: the clinical management of congenital chloride diarrhoea. Aliment Pharmacol Ther 2010; 31(4): 477-85. http://dx.doi.org/10.1111/j.1365-2036.2009.04197.x
Badawi MH, Zaki M, Ismail EA, Majid MA. Congenital chloride diarrhoea in Kuwait: a clinical reappraisal. J Trop Pediatr 1998; 44(5): 296-9. http://dx.doi.org/10.1093/tropej/44.5.296
Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006; (3): CD004454.
