Levels of Serum IgA in Healthy Blood Donors
DOI:
https://doi.org/10.14205/2310-6980.2014.02.02.1Keywords:
IgA deficiency, blood donors, transfusion reaction.Abstract
Objectives: We evaluate that the prevalence of immunoglobulin A deficiency in Turkish blood donors. The most of authors describe an IgA concentration of<5 mg/dL-1 as IgA deficiency and has been broadly studied in different ethnic groups. The patients with IgA deficiency may form specific antibodies against IgA. The antibodies against IgA can cause an anaphylactic response when the patient receives an IgA-containing blood transfusion.
Methods: The blood samples were taken after blood donation. These serum samples stored at -20ºC until analysis. The amount of serum IgA was measured using the Dade Behring assay with automated Dade Behring Nephelometer (Dade Behring Marburg GmbH, Marburg, Germany).
Results: Of the total 1077 healthy blood donors screened, none of the donors was found to be selective IgA deficiency.
Conclusion: The incidence of IgA deficiency in Turkish blood donors is very low. But, anaphylaxis risks exist in performing blood transfusion to IgA-deficient individual, and measures should be taken to reduce IgA anaphylaxis.
References
Litzman J, Sevcíková I, Stikarovská D, Pikulová Z, Pazdírková A, Lokaj J. IgA deficiency in Czech healthy individuals and selected patient groups. Int Arch Allergy Immunol 2000; 123(2): 177-80. http://dx.doi.org/10.1159/000024438
Aghamohammadi A, Cheraghi T, Gharagozlou M, Movahedi M, Rezaei N, Yeganeh M, et al. IgA deficiency: correlation between clinical and immunological phenotypes. Journal of Clinical Immunology 2009; 29(1): 130-136. http://dx.doi.org/10.1007/s10875-008-9229-9
Hanson LA. Selective IgA-deficiency. In: Chandra RK, editors. Primary and Secondary Immuno-deficiency Disorders. New York: Churchill Livingstone 1983; pp. 62-84
Saghafi S, Pourpak Z, Aghamohammadi A, Pourfathollah AA, Samadian A, Farghadan M, et al. Selective immunoglobulin A deficiency in Iranian blood donors: prevalence, laboratory and clinical findings. Iran J Allergy Asthma Immunol 2008; 7(3): 157-62.
Laschinger C, Gauthier D, Valet JP, Naylor DH. Fluctuating levels of serum IgA in individuals with selective IgA deficiency. Vox Sanguinis 1984; 47(1): 60-7. http://dx.doi.org/10.1111/j.1423-0410.1984.tb01562.x
Anani W, Triulzi D, Yazer MH, QuL. Relative IgA-deficient recipients have an increased risk of severe allergic transfusion reactions. Vox Sang 2014; 107(4): 389-92. http://dx.doi.org/10.1111/vox.12192
Alam A, Cserti-Gazdewich CM. Perioperative management of an IgA-deficient recipient of a double-lung transplant. Can J Anaesth 2014; 61(5): 441-5. http://dx.doi.org/10.1007/s12630-014-0133-x
Feng ML, Zhao YL, Shen T, Huang H, Yin B, Liu RZ, et al. Prevalence of immunoglobulin A deficiency in Chinese blood donors and evaluation of anaphylactic transfusion reaction risk. Transfus Med 2011; 21(5): 338-43. http://dx.doi.org/10.1111/j.1365-3148.2011.01082.x
Kiani-Alikhan S, Yong PF, Grosse-Kreul D, Height SE, Mijovic A, Suddle AR, et al. Successful desensitization to immunoglobulin A in a case of transfusion-related anaphylaxis. Transfusion 2010; 50(9): 1897-901. http://dx.doi.org/10.1111/j.1537-2995.2010.02662.x
Rezvan H, Ahmadi D, Esmailzadeh S, DayhimiI. Selective deficiency of immunoglobulin A among healthy voluntary blood donors in Iran. Blood Transfus 2009; 7(2): 152-4.
Thibault L, Beauséjour A, de Grandmont MJ, Long A, Goldman M, Chevrier MC. Establishment of an immunoglobulin A-deficient blood donor registry with a simple in-house screening enzyme-linked immunosorbent assay. Transfusion 2006; 46(12): 2115-21. http://dx.doi.org/10.1111/j.1537-2995.2006.01037.x
Palmer DS, O'Toole J, Montreuil T, Scalia V, Goldman M. Evaluation of particle gel immunoassays for the detection of severe immunoglobulin A deficiency and anti-human immunoglobulin A antibodies. Transfusion 2012; 52(8): 1792- 8. http://dx.doi.org/10.1111/j.1537-2995.2011.03513.x
Kumar ND, Sharma S, Sethi S, Singh RP. Anaphylactoid transfusion reaction with anti-IgA antibodies in an IgA deficient patient: a case report. Indian J Pathol Microbiol 1993; 36(3): 282-4.
Vassallo RR. Review: IgA anaphylactic transfusion reactions. Part I. Laboratory diagnosis, incidence, and supply of IgAdeficient products. Immunohematology 2004; 20(4): 226-33.
Holt PD, Tandy NP, Anstee DJ. Screening of blood donors for IgA deficiency: a study of the donor population of southwest England. J Clin Pathol 1977; 30(11): 1007-10. http://dx.doi.org/10.1136/jcp.30.11.1007
Wells JV, McNally MP, King MA. Selective IgA deficiency in Australian blood donors. Aust N Z J Med 1980; 10(4): 410-3. http://dx.doi.org/10.1111/j.1445-5994.1980.tb04091.x
Ropars C, Muller A, Paint N, Beige D, Avenard G. Large scale detection of IgA deficient blood donors. J Immunol Methods 1982; 54(2): 183-9. http://dx.doi.org/10.1016/0022-1759(82)90059-X
Clark JA, Callicoat PA, Brenner NA, Bradley CA, Smith DM Jr. Selective IgA deficiency in blood donors. Am J Clin Pathol 1983; 80(2): 210-3.
Kanoh T, Mizumoto T, Yasuda N, Koya M, Ohno Y, Uchino H, et al. Selective IgA deficiency in Japanese blood donors: frequency and statistical analysis. Vox Sang 1986; 50(2): 81- 6. http://dx.doi.org/10.1111/j.1423-0410.1986.tb04851.x
Chandran S, Khetan D, Chaudhary R, Misra R, Aggarwal A. Low prevalence of IgA deficiency in north Indian population. Indian J Med Res 2006; 123(5): 653-6.
