Does the E2/P Ratio Predictor have a Role in the IVF Outcome during Ovulation İnduction? - (Pages 18-23)

Mehmet Yaman1 , Murat Alan1,*, Hakkı Aytaç2 , Yasemin Alan2 , İbrahim Egemen Ertaş1 and Bulent Yılmaz1.

1Health Sciences University Tepecik Education and Research Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey
2Department of Obstetrics and Gynecology, İzmir Metropolitan Municipality Eşrefpaşa Hospital, İzmir, Turkey


Abstract: Objective: The present study investigates the role of hCG day serum P/E ratio in predicting the chemical pregnancy rate in cycles subject to in vitro fertilization – intracytoplasmic sperm injection – embryo transfer (IVF-ICSI-ET) following controlled ovarian stimulation (COS) accompanied by gonadotropin-releasing hormone agonists (GnRH).
Methods: The study retrospectively examined a total of 2,517 patients treated with IVF.All patients underwent an oocyte pick-up (OPU) procedure, and subjects were included in the GnRH-agonist short protocol study upon a total of 140 fresh embryo transfers based on inclusion/exclusion criteria.
Findings: The hCG day P/E ratio of the patients that did not end in chemical pregnancy was found 0.7415 ± 0.0010285, which was 2.4637 ± 0.0099075 for those ended in chemical pregnancy. The P/E ratio of patients with and without chemical pregnancy was not statistically significant (p=0.718).
Conclusion: In IVF patients subject to fresh embryo transfer and administered an agonist cycle, the ratio of serum P level to the E level on the same day does not seem to be an effective parameter in predicting the rate of chemical pregnancy.Further studies with wider series of patient populations are required to clarify this matter.

Keywords: Gonadotropin-releasing hormone agonist protocol, hCG-day, progesterone, progesterone/estradiol ratio.