Thermoregulatory Response to Aminoacid Infusion during Spinal Anaesthesia - Pages 31-37

Emine Muftuoglu1, G. Ulufer Sivrikaya2, Ayse Hanci3, Melahat K. Erol4 and Selbiye Karagulle5

1Yalova Hospital-Department of Anaesthesiology, Yalova, Turkey; 2Antalya Training and Research Hospital-Department of Anaesthesiology and Reanimation, Antalya, Turkey; 3Sisli Etfal Training and Research Hospital-Department of Anaesthesiology and Reanimation, Istanbul, Turkey; 4Bagcilar Training and Research Hospital-Department of Anaesthesiology and Reanimation, Istanbul, Turkey; 5Bagcilar Special Tekden Hospital-Department of Anaesthesiology, Istanbul, Turkey

DOI: http://dx.doi.org/10.14205/2310-9394.2014.02.02.2

Abstract:

Background: Perioperative hypothermia is a common and a major problem in general anaesthesia and neuraxial anaesthesia. Preoperative infusion of amino acids (AA)s is known to prevent perioperative hypothermia during general anaesthesia. We tested the hypothesis that AA infusions given via the intravenous route would also cause thermogenic stimulation under spinal anaesthesia.

Methods: Eighty patients undergoing transurethral tumour resection under spinal anaesthesia were divided into two groups: AA infusion (AA group) starting 1 h before surgery and continued during surgery; saline infusion (control group). The temperature in the tympanic membrane was recorded immediately before infusion commencement and continued throughout anaesthesia. Sensory block level and haemodynamic parameters were recorded during anaesthesia. Postoperative shivering was assessed in postoperative care unit.

Results: Body core (Tcore) values decreased during the study period in comparison with baseline values in the control group. The AA group had significantly higher Tcore values during anaesthesia and surgery compared with the control group. Mean sensory block level and haemodynamic parameters were comparable between the two groups. Shivering occurred significantly more frequently in the control group than in the AA group.

Conclusion: AA infusions can prevent spinal anaesthesia-induced hypothermia without any effects on sensory block level and haemodynamics.

Keywords: Anaesthesia, spinal, aminoacid, thermoregulatory.