Future Local Anesthetics – Neurotoxins? - Pages 11-15
Prasanna Vadhanan and G. Narendren
Department of Anaesthesiology, Vinayaka Missions Medical College and Hospital, Karaikal, Pondicherry, India
The currently available local anaesthetics are non-specific blockers of the voltage gated sodium channels. Neurotoxins, derived from various sources are very potent and specific sodium channel blockers. Their site is also quite different from local anaesthetics. Their major toxic manifestation is muscle paralysis, which is easier to manage as compared to the serious cardiac and neurological side effects of local anaesthetics. These properties make neurotoxins almost an ideal local anaesthetic. A brief mention of the currently available neurotoxins and early studies with them are summarized.
Keywords: Local anaesthetics, Neurotoxins.