Levels of Serum IgA in Healthy Blood Donors - Pages 29-31
Arslan Ş.1, Doğan M.2, Baykan M.2 and Karaarslan H.3
1Immunology and Allergy Departments, Necmettin Erbakan University, Meram Medical School, Konya, Turkey; 2Medica Microbiology Departments, Necmettin Erbakan University, Meram Medical School, Konya, Turkey; 3Gastroenterology Clinics, Medicana Private Hospital, Konya, Turkey
Objectives: We evaluate that the prevalence of immunoglobulin A deficiency in Turkish blood donors. The most of authors describe an IgA concentration of<5 mg/dL−1 as IgA deficiency and has been broadly studied in different ethnic groups. The patients with IgA deficiency may form specific antibodies against IgA. The antibodies against IgA can cause an anaphylactic response when the patient receives an IgA-containing blood transfusion.
Methods: The blood samples were taken after blood donation. These serum samples stored at -20ºC until analysis. The amount of serum IgA was measured using the Dade Behring assay with automated Dade Behring Nephelometer (Dade Behring Marburg GmbH, Marburg, Germany).
Results: Of the total 1077 healthy blood donors screened, none of the donors was found to be selective IgA deficiency.
Conclusion: The incidence of IgA deficiency in Turkish blood donors is very low. But, anaphylaxis risks exist in performing blood transfusion to IgA-deficient individual, and measures should be taken to reduce IgA anaphylaxis.
Keywords: IgA deficiency, blood donors, transfusion reaction.