Restoring Immune Tolerance in Atherosclerosis: Role of Regulatory Immune Response in Atheroprotection (Pages 32-44)

Vijay. V. Kakkar1,2

1Molecular Immunology Unit, 2Scientific Chairman, Thrombosis Research Institute, Bangalore, India, President, Thrombosis Research Institute, London, UK

DOI: http://dx.doi.org/10.14205/2310-6980.2014.02.02.2

Abstract: Cardiovascular diseases remain the most significant cause of global mortality despite advances in medicine and new drug development. Atherosclerotic lesions start developing in childhood, progress over decades and manifest as coronary artery disease, stroke or peripheral arterial disease later in life. Chronic inflammation in the arterial wall mediated by altered immune response is vital during the development of atherosclerosis. Antigen specific immune therapy is an elegant approach to target disease related antigens. Immune tolerance to atherogenic self antigens has gained importance as an efficient therapy to control atherosclerosis in recent years. This review discusses the recent development and our understanding of immune tolerance in atherosclerosis and the role of regulatory immune response in protection against the disease.

Keywords: Atherosclerosis, Autoimmunity, Immune tolerance, Regulatory T cells.