Leptin as an Important Hormone and Immunomodulator in Adult and Childhood Rheumatoid Arthritis (Pages 16-24)
Agata Brzeska, Joanna Świdrowska and Elżbieta Smolewska
Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Poland
Abstract: Leptin is a polypeptide hormone playing an important role in the regulation of the body weight, since several its biological functions are involved in the pathogenesis of musculoskeletal system inflammation. Moreover, leptin is a potent immunomodulator which takes a part in the regulation of both innate and adaptive immunities. The role of this hormone in the pathogenesis of the chronic arthritis is actually a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, in limited extend, in children with juvenile idiopathic arthritis (JIA). Recent studies showed a significant correlation between leptin serum concentration and the body mass indices in either RA or JIA patients, indicating its role in the regulation of body mass during development of chronic inflammatory process. The serum leptin level may correlate with an action of several pro-inflammatory cytokines, released locally into the synovial fluid. This may be connected with the disease activity, but may be also determined by the type of introduced treatment.
The aim of this paper is a state of art on multidirectional activity of leptin and its cooperation with other biological mediators, including pro-inflammatory cytokines, in adult and childhood rheumatoid arthritis.
Keywords: Leptin, rheumatoid arthritis, juvenile idiopathic arthritis.